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. 2016 Jun 3;35:87. doi: 10.1186/s13046-016-0366-3

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — HBwx promoted activation of ERK by inhibiting the RKIP expression. Expressions of RKIP, ERK, and p-ERK in stable transfected cell lines with HBwx and HBx were detected by Western blot. In both HBwx and HBx cells, RKIP expression was donwregulated, p-ERK expression was upregulated