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. 2016 Jun 3;4:57. doi: 10.1186/s40478-016-0321-8

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© Apps et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — a Three dimensional annotation of an area of case 1. Green indicates the border of tumour demonstrating nodules and islands with some interconnections. Connections of less than 5 μm will not be well visualised at this resolution, possibly explaining discontinuities. Purple indicates epithelial whorls/clusters. b An area of finger-like protrusions. The upper panel shows the micro-CT image; the lower panel shows 3D annotation revealing a complex 3D structure in this region. c Immuno-histochemical staining of the post micro-CT samples in (A) demonstrating appropriate antigenic reactivity following iodination. Upper panel beta-catenin showing a cluster with nucleo-cytoplasmic accumulation (case 3), lower panel glial fibrillary acidic protein (GFAP) (case 1). Scale bars indicate 100 μm