Table 5.
IPA-identified “top canonical pathways” enriched by CBD treatment in stimulated TMOG cells
| Canonical pathways | Annotated genes | p value |
|---|---|---|
| IL-10 signaling | Hmox1, Il1b, Jun, Socs3 | 0.0039 |
| IL-6 signaling | Il1b, Jun, Socs3, Srf, Vegfa | 0.0042 |
| cAMP-mediated signaling | Crem, Fpr2, Gnal, Grm6, Hrh3 | 0.024 |
| IGF-1 signaling | Igfbp4, Jun, Socs3, Srf | 0.015 |
| Fcγ receptor mediated phagocytosis in macrophages and monocytes | Appc3, Hck, Hmox1, Vav3 | 0.012 |
| Superpathway of cholesterol biosynthesis | Fdps, Sqle | 0.016 |
| T helper cell differentiation | CD40, Ifbgr1, Il21 | 0.042 |