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. 2016 Apr 20;3(6):422–433. doi: 10.1002/acn3.310

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© 2016 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Distribution of expanded T‐cell clonotypes in the peripheral blood and cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients and idiopathic intracranial hypertension (IIH) controls. Clonotype distribution as a function of expansion in the peripheral blood (PB) (A) and CSF (B) of MS patients (dashed red line) and IIH controls (dashed green line). Subsets of differentially expanded clones in PB (from −9.9 to −5.1 log frequency; gray shading) and CSF (from −5.7 to −3.2 log frequency; gray shading) were selected for phylogenetic tree analysis (Fig. 5). Number of shared clonotypes by CDR3 amino acid sequence across MS patients and IIH controls in PB (C) and CSF (D).