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. Author manuscript; available in PMC: 2016 Jun 3.
Published in final edited form as: Gynecol Oncol. 2014 Dec 17;136(3):542–548. doi: 10.1016/j.ygyno.2014.12.017

Table 2A.

Gene-level AML test and most significantly associated SNP (MAFa ≥ 0.05) in each gonadotropin signaling gene for invasive high-grade serous and mucinous ovarian cancers.

Gene Coverage
(at r2 ≥ 0.8)		 Serous high grade (n = 6258)
Mucinous (n = 991)
No. of
signif.
SNPs		 AML
burden
testb 		Most significant
SNP		 MAFa Imput.
r2 		ORc p-Value No. of
signif.
SNPs		 AML
burden
testb 		Most significant
SNP		 MAFa Imput.
r2 		ORc p-Value
ACVR1 0.55 0 0.47 N/A – – – – 1 0.76 rs17804523 0.07 0.67 0.79 0.042
ACVR2 0.98 1 0.66 rs57870939 0.05 0.60 1.13 0.038 6 0.38 rs11681013 0.08 0.74 1.23 0.025
CGA 0.97 0 0.69 N/A – – – – 1 0.50 chr6:87820107:I 0.29 0.89 1.11 0.039
FSHB 0.99 1 0.35 rs7925340 0.21 0.99 1.05 0.049 37 0.11 rs12577729 0.22 0.95 1.14 0.018
FSHR 0.90 31 0.52 rs116044731 0.07 0.80 0.87 0.003 45 0.33 rs12997920 0.39 0.88 1.13 0.010
GNRH 1.00 12 0.041 chr8:25283745:D 0.42 0.62 1.07 0.010 0 0.40 N/A – – – –
GNRHR 0.94 0 0.34 N/A – – – – 0 0.78 N/A – – – –
INHA 0.86 5 0.24 rs77120825 0.06 0.51 1.16 0.013 0 0.43 N/A – – – –
INHBA 1.00 2 0.52 rs17719440 0.08 0.98 1.11 0.008 0 0.55 N/A – – – –
INHBB 0.82 12 0.15 rs4328642 0.05 0.58 0.86 0.010 26 0.045 rs6542591 0.39 0.67 1.17 0.003
LHCGR 0.97 90 0.046 rs13426172 0.12 1.00 0.91 0.005 21 0.67 rs55871926 0.10 0.80 1.26 0.004
Global – 154 0.24 – – – – – 137 0.54 – – – – –

Note: “N/A” reflects genes with no significant SNPs at p ≥ 0.05. “Global” refers to when all genes are considered.

a

MAF = minor allele frequency.

b

AML = admixture maximum likelihood, taking into account the first five ancestry principal components; p-values for trend reported.

c

OR = per allele odds ratio, taking into account study set and the first five ancestry principal components.