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. Author manuscript; available in PMC: 2016 Jun 3.
Published in final edited form as: Am J Obstet Gynecol. 2014 Dec 31;212(5):653.e1–653.16. doi: 10.1016/j.ajog.2014.12.041

FIGURE 3. PCoA plots of beta diversity by body mass index.

FIGURE 3

The placental microbiome does not vary with obesity. Principle coordinate analysis of all operational taxonomic units generated by 16S recombinant RNA sequencing is shown on the left. There was no significant difference in between-subject beta-diversity by virtue of obesity (permutational multivariate analysis of variance, P = .161). Among preterm placentas, the placental microbiome does not vary with obesity. Principle coordinate analysis of all operational taxonomic units generated by 16S recombinant RNA sequencing of only the preterm women is shown on the right. There was no significant difference in between-subject beta-diversity by virtue of obesity (permutational multivariate analysis of variance, P = .48). Among all women, the placental microbiome does not vary with GWG. There was no significant difference in between-subject beta-diversity by virtue of excess GWG (permutational multivariate analysis of variance, P = .186). The microbiome of preterm placentas does vary with GWG. There was statistically significant clustering by virtue of excess GWG (permutational multivariate analysis of variance, P = .022) that was most apparent along the PC1 axis (Wilcoxon rank sum, P = .02).

GWG, gestational weight gain; PCoA, principal coordinate analysis; PERMANOVA, permutational multivariate analysis of variance.

Antony. The preterm placental microbiome varies with excess weight gain. Am J Obstet Gynecol 2015.