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Overall effect of diet and nutrition on spermatogenesis. Increased intake of unhealthy diet may lead to impaired spermatogenesis due to elevated cholesterol, leptin, reactive oxygen species, and fat-soluble toxicants. Abbreviations: FSH, follicle-stimulating hormone; GnRH, gonadotropin-releasing hormone; LC, Leydig cells; LH, luteinizing hormone; ROS, reactive oxygen species; SC, Sertoli cells.
