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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: J Crohns Colitis. 2016 Feb 29;10(9):1087–1095. doi: 10.1093/ecco-jcc/jjw061

Fig. 2. CRTH2 antagonist OC-459 improves while DP antagonist MK0524 worsens TNBS-induced colitis.

Fig. 2

(A) OC-459 (OC), but not MK0524 (MK) (C), decreased inflammation scores, and prevented (B) colon shortening and (D) cytokine production vs. vehicle (VEH)-treated mice. (E) CRTH2-immunoreactivity in the lamina propria and epithelial cells in sections of mouse colon. Means±SD; *p<0.05; ***p<0.001; one-way ANOVA, n=6-10. Controls (CTRL, no TNBS).