Table 3.
Frequency of nut consumption (28g serving) | ||||||||
---|---|---|---|---|---|---|---|---|
Cases | Person-years | Never | 1–3 times/month | Once/week | ≥ 2 times/week | Ptrend | Pinteraction | |
Nut intake, servings/d | 0 | 0.01–0.09 | 0.10–0.19 | ≥ 0.20 | ||||
Body mass index (BMI) | 0.14 | |||||||
< 25 kg/m2 | 603 | 943,976 | 1.00 | 0.85 (0.66, 1.08) | 0.88 (0.67, 1.17) | 0.91 (0.69, 1.20) | 0.93 | |
≥ 25kg/m2 | 733 | 905,415 | 1.00 | 1.13 (0.90, 1.42) | 1.11 (0.85, 1.45) | 0.82 (0.62, 1.09) | 0.01 | |
Physical activity† | 0.20 | |||||||
High physical activity | 693 | 1,080,247 | 1.00 | 0.97 (0.77, 1.24) | 0.95 (0.72, 1.25) | 0.78 (0.59, 1.03) | 0.02 | |
Low physical activity | 755 | 910,096 | 1.00 | 1.04 (0.84, 1.30) | 1.04 (0.80, 1.34) | 1.01 (0.78, 1.32) | 0.89 | |
BMI and Physical activity | 0.94 | |||||||
BMI<25 and high physical activity | 318 | 565,384 | 1.00 | 0.90 (0.63, 1.27) | 0.80 (0.53, 1.19) | 0.78 (0.53, 1.17) | 0.27 | |
Intermediate group | 603 | 800,522 | 1.00 | 1.00 (0.78, 1.29) | 1.13 (0.84, 1.50) | 0.96 (0.71, 1.30) | 0.72 | |
BMI≥25 and low | 399 | 458,321 | 1.00 | 1.07 (0.79, 1.44) | 1.01 (0.71, 1.45) | 0.78 (0.53, 1.15) | 0.07 |
Adjusted for age (month), physical activity (metabolic-equivalents/week, quintiles), family history of colorectal cancer (yes/no), history of previous lower endoscopy (yes/no), history of ulcerative colitis (yes/no), history of polyps (yes/no), aspirin use (<1, 1–3, 3.1–7, >7 tablets/week), multivitamin use (yes/no), pack-years of smoking (never smoker, 1–9, 10–24,25–44, and ≥ 45 pack-years), alcohol intake (never, 0.1–5, 5.1–15, > 15 g/d), and total energy intake (kcal, continuous), body-mass index (<22, 22–22.9, 23–24.9, 25–28.9, ≥29 kg/m2), and history of diabetes mellitus (yes/no).
High physical activity group was defined by metabolic-equivalents/week more than the median level; low physical activity group was defined by metabolic-equivalents per week less than or equal to median level.