Table 4. The Effects of miR-27a/b on body weight and plasma lipid profile in apoE KO mice.
| BW(g) | TG | TC | HDL-C | LDL-C | |
|---|---|---|---|---|---|
| AG-NC | 27.62±1.25 | 2.38±0.26 | 18.77±1.39 | 3.12±0.46 | 15.20±0.61 |
| AGa | 28.04±1.72 | 3.67±0.28* | 14.03±1.57* | 2.99±0.53 | 12.14±1.25* |
| AGb | 27.72±1.20 | 3.59±0.37* | 14.64±0.96* | 2.92±0.49 | 11.70±1.58* |
| AN-NC | 28.33±0.76 | 2.33±0.24 | 18.58±0.86 | 3.05±0.62 | 15.50±0.80 |
| ANa | 28.19±1.42 | 1.39±0.27# | 23.11±1.04# | 3.14±0.62 | 18.19±0.86# |
| ANb | 27.87±0.80 | 1.30±0.25# | 22.47±1.05# | 3.23±0.54 | 18.59±0.91# |
Plasma lipids from different experimental groups were measured with enzymatic methods. Unit: (mmol/L). AG-NC: miR-27a/b agomir negative control; AGa: miR-27a agomir; AGb: miR-27b agomir; AN-NC: miR-27a/b antagomir negative control; ANa: miR-27a antagomir; ANb: miR-27b antagomir; BW: body weight; TG: triglyceride; TC: total cholesterol; HDL-C: high density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol. All the results are expressed as means ± SD from the indicated numbers of male apoE KO mice in each group (n = 10 mice per group).
*P <0.05, vs AG-NC.
#P <0.05, vs AN-NC.