Pattern recognition receptors (PRRs) |
|
|
peptidoglycan recognition proteins (PGRPs) |
23 |
|
gram-negative bacteria binding proteins (GNBPs) |
3 |
|
Collectins |
53 |
|
Ficolins |
30 |
|
c-type lectins |
110 |
|
macrophage mannose receptors |
237 |
|
scavenger receptors (SRs) |
26 |
based on domain information in [56] |
thioester-containing proteins (TEPs) |
31 |
|
fibrinogen-related proteins (FREPs) |
40 |
|
down syndrome cell adhesion molecule (DSCAM) |
11 |
|
Galectins |
20 |
|
Toll-like receptors (TLRs) |
220 |
|
interferon-induced helicase c domain-containing protein 1 (MDA5)/(also RIG-I called) DDX58 |
22 |
|
stabilin-2 |
3 |
|
Immune signaling pathways |
|
|
myeloid differentiation primary response protein 88 (MyD88) |
14 |
|
sterile alpha and TIR domain containing protein (SARM1) |
3 |
|
IL-1R-associated kinase (IRAK) |
1 |
|
tumor necrosis factor [TNF] receptor-associated factor (TRAF) |
31 |
TRAF7 (8), TRAF6 (3), TRAF2 (3), TRAF4 (3), TRAF3 (1), TRAF6-like isoform 1 (1) |
inhibitor of nuclear factor kappa-b kinase (IKK) |
6 |
|
transforming-growth-factor [TGF]-β-activated kinase 1 (TAK1, also called MEKK7) |
6 |
|
TAK1-binding protein (TAB1) |
3 |
|
TAK1-binding protein 2 (TAB2) |
2 |
|
nuclear factor [NF]-κB essential modulator (NEMO) |
2 |
|
TRAF-family-member-associated NF-κB activator-binding kinase 1 (TBK1) |
13 |
|
inhibitor of nuclear factor-κB (IκB) |
4 |
|
nuclear factor of kappa light polypeptide gene enhancer in b-cells 2, p49/p100 (NFκB2) |
2 |
|
activator protein 1 (AP-1) |
1 |
|
interferon regulatory factor (IRF) |
7 |
|
janus activated kinase (JAK) |
2 |
|
signal transducer and activator of transcription (STAT) |
4 |
|
mitogen-activated protein kinases (MAPK) |
13 |
MAPK3 (1), MAPK14 (4), MAPK15 (2), MAPK6 (3) and MAPK7 (1) |
mitogen-activated protein kinase kinase (MEK also called MKK) |
11 |
|
mitogen-activated protein kinase kinase kinase (MAP3K or MEKK) |
34 |
MEKK1 (2), MEKK19 (8), MEKK2 (1), MEKK10 (1), MEKK15 (1), MEKK9 (1), MEKK13 (2) |
mitogen-activated protein kinase kinase kinase MLT-like isoform 1 (also called ZAK isoform 1) |
1 |
|
mitogen-activated protein kinase kinase kinase kinase (MAP4K) |
10 |
MAP4K3 (6) and MAP4K5 (4) |
receptor-interacting protein 1 (RIP1) |
3 |
|
Pellino |
2 |
|
toll-interacting protein (TOLLIP) |
1 |
|
suppressor of cytokine signaling (SOCS) |
5 |
|
NF-kappa-B inhibitor-like protein 1 (NFKBIL1) |
1 |
|
interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1BP1) |
1 |
|
mitochondrial antiviral-signaling protein (MAVS) |
1 |
|
nuclear factor of activated T-cells (NFAT) |
1 |
|
c-jun-amino terminal kinase-interacting protein 4 (JIP4) |
12 |
|
c-jun-amino terminal kinase-interacting protein 1 (JIP1) |
1 |
|
endogenous ligands |
|
|
fibrinogen (α/β/γ-chain) |
8 |
|
heat shock protein [Hsp]20 family |
13 |
|
Hsp70 family |
40 |
|
Hsp90 family |
25 |
|
Hsp60 |
2 |
|
Hsp10 |
1 |
|
stress-induced-phosphoprotein 1 (STIP1) |
2 |
|
intraflagellar transport protein 25 homolog (Hspb11) |
2 |
|
Hypoxia-inducible factors (HIFs) |
|
|
HIF-1α / HIF-2α |
6 |
|
HIF-1β |
2 |
|
hypoxia-inducible factor 1-α inhibitor (HIF1AN) |
1 |
|
prolyl hydorxylases (PHD) |
2 |
|
p300 / CREB-binding protein (CBP) |
13 |
|
Immune effectors |
|
|
Antioxidant defence system/phagocytosis |
|
|
superoxide dismutase (SOD) |
25 |
with mitochondrial manganese-SOD domains (4) and copper/zinc-SOD domains (21) |
catalase (CAT) |
7 |
|
glutathione peroxidase (GPX) |
7 |
|
nitric oxide synthase (NOS) |
2 |
|
Thioredoxin |
6 |
|
thioredoxin reductase |
4 |
|
Peroxiredoxin |
11 |
|
Glutaredoxin |
6 |
|
glutathione S-transferase (GST) |
53 |
|
glutathione synthase (GS) |
2 |
|
glutamate—cysteine ligase regulatory subunit |
1 |
|
glutamate—cysteine ligase catalytic subunit |
3 |
|
methionine sulfoxide reductase A |
3 |
|
methionine-R-sulfoxide reductase B3 |
4 |
|
glutathione reductase (mitochondrial) |
1 |
|
NADPH oxidase (NOX) |
4 |
|
p67phox
|
1 |
|
cytochrome b-245 heavy chain-like (gp91phox) |
1 |
|
cytochrome b-245 light chain-like (p22phox) |
1 |
|
dual oxidase (DUOX) |
7 |
|
small GTPase Rac |
2 |
|
evolutionarily conserved signaling intermediate in toll pathways, mitochondrial (ECSIT) |
1 |
|
Cathepsin |
59 |
cathepsin B (9), F (3), L (17), C (1), O (2), Z (1), D (3) |
Lysozymes |
16 |
|
Antimicrobial peptides |
|
|
big defensins |
5 |
|
Hydramacin |
1 |
|
bactericidal permeability increasing protein (BPI) |
27 |
|
cytokines and cytokine receptors |
|
|
macrophage migration inhibitory factor (MIF) |
3 |
|
interleukin [IL]-17 |
3 |
|
interleukin-17 receptor d |
5 |
|
interleukin-6 receptor |
12 |
|
Others |
|
|
Septin |
7 |
|
c4b-binding protein alpha/beta chain |
8 |
|
Apoptosis |
|
|
FAS-associated death domain protein (FADD) |
3 |
|
TNF receptor superfamily members |
9 |
|
TNF superfamily members |
8 |
|
apoptosis-inducing factor 1, mitochondrial (AIF) |
1 |
|
Bax |
2 |
|
Caspases |
114 |
|
baculoviral IAP repeat-containing proteins (IAPs) |
75 |
|
direct IAP-binding protein of low isoelectric point (DIABLO) |
4 |
|
interferon alpha-inducible protein 27 (IFI27) |
25 |
|