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. Author manuscript; available in PMC: 2016 Jun 3.
Published in final edited form as: Cell Rep. 2016 May 19;15(9):1901–1909. doi: 10.1016/j.celrep.2016.04.080

Figure 2. The constellation of hematopoietic phenotypes observed in N10-Siae mice are Mendelian, recessive & unlinked to Siae.

Figure 2

(A) (N10-Siae × C57BL/6J) F1 animals have a normal CD8+ MP cell compartment. Upon subsequent backcrossing to the N10-Siae background, Siae does not segregate with the altered CD8+ MP cells (n=13). Approximately equal number of mice with (n=79) and without (n=77) the phenotype (<40% and >40% CD8 MP cells respectively) are observed. (B) A strong correlation between loss of marginal zone B cells and increase in CD8 MP is observed. (C) ~25% of Siae+/+ (wild-type) mice obtained from an intercross between heterozygous N10-Siae mice exhibit normal CD8+ MP cells.