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. 2016 Jun 3;11(6):e0156798. doi: 10.1371/journal.pone.0156798

Fig 1. Anti-RSV F antibodies identified from Morphosys HuCAL GOLD® phage display libraries.

Fig 1

Heavy chain C-terminal 6xHis tagged antigen specific bivalent Fabs were purified with Ni-NTA column and then tested in ELISA binding to RSV prefusion and postfusion F proteins. (A) Antibodies preferentially binding to RSV postfusion F protein; (B) Antibodies binding to both RSV postfusion and prefusion F proteins; (C) antibody binding specifically to RSV prefusion F protein. Full-length human IgG1 D25 (prefusion F specific) and palivizumab (binding to both prefusion and postfusion F) were used as control antibodies in the above experiments.