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. 2016 Jun 3;11(6):e0155990. doi: 10.1371/journal.pone.0155990

Fig 5. Schematic demonstrating the proposed mechanism of mvsFlt action.

Fig 5

A) sFlt (red, unconjugated) and mvsFlt (red conjugated blue chain of HyA) are injected into a diabetic retina where there is a high concentration of VEGF (green circles). B) After a given time, t, the majority of the sFlt has been cleared from the vitreous and VEGF is thus able to induce blood vessel growth. mvsFlt has a longer residence time in the vitreous and is able to bind and inhibit VEGF over much longer periods of time, leading to prolonged inhibition of retinal angiogenesis.