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. 2016 May 1;9(5):541–552. doi: 10.1242/dmm.024513

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Class I and II HDACs are upregulated in human abdominal aortic aneurysm (AAA). (A) Class I and IIa HDAC mRNA levels analysed by quantitative real-time PCR in abdominal aorta from AAA patients and donors (controls). Values shown are the mean±s.e.m. (AAA: n=22; donors: n=14). (B) Representative western blot analysis of HDAC1, 2, 4 and 7 (left panel) and their corresponding quantitative histogram (right panel; AAA: n=1; donors: n=8). (C) Representative immunostaining for HDAC1, 2, 4 and 7 in haematoxylin-counterstained aortic samples from AAA patients and controls. Scale bars: 50 μm. IC, inflammatory cells; VSMC, vascular smooth muscle cells. Arrows indicate positively stained cells. (D) Densitometric analysis of Ac-H3K18 protein levels analysed by western blot (shown in B) and immunohistochemistry in haematoxylin-counterstained aortic samples from AAA patients and controls. Results are expressed as mean±s.e.m. *P≤0.05 vs donors (t-test and one-way ANOVA).