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. 2016 May 1;9(5):541–552. doi: 10.1242/dmm.024513

Fig. 2.

Fig. 2.

The progression of abdominal aortic aneurysm (AAA) is limited by class I and class IIa HDAC inhibitors. ApoE−/− mice were infused with saline or Ang II and were treated or not with MC-1568 (MC), MS-275 (MS) or doxycycline (Dox). (A) Graph showing the survival rates of each group of animals. Please note that data from the MC-1568 group, represented by an opened diamond, overlap the open circle symbol corresponding to saline-infused animals. All animals from both saline and MC-1568 groups survived until the end of the study. *P<0.05 vs saline at 28 days; #P<0.05 vs Ang II at 28 days (Kaplan–Meier analysis). (B) Time-course analysis of abdominal aortic diameters (mm) evaluated by ultrasonography at 0, 14 and 28 days of Ang II infusion in each group. Data are expressed as mean±s.e.m. *P<0.05 vs saline at 14 and 28 days; #P<0.05 vs Ang II at 28 days; and $P<0.05 Ang II vs Ang II+MC-1568 at 14 days (two-way ANOVA/Bonferroni test). (C) Maximal suprarenal abdominal aortic diameter (in mm) measured from transverse ultrasound images at day 28 post-infusion. Data are expressed as mean±s.e.m. *P<0.05 vs saline; #P<0.05 vs Ang II (one-way ANOVA/Mann–Whitney test). (D) Representative high-frequency ultrasound frames of abdominal aortas from all groups. Transverse (top) and longitudinal (bottom) images were taken at the level of the suprarenal aorta. AA, abdominal aorta; L, length. (E) Representative images of fixed aortas. The histogram represents the incidence of AAA (including AAA-related mortality) in percentage in each group (n=10-13). *P<0.05 vs saline; #P<0.05 vs Ang II (χ2 test).