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. 2016 May 1;9(5):541–552. doi: 10.1242/dmm.024513

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — HDAC inhibitors limit vascular expression of proinflammatory markers in the abdominal aorta from Ang-II-infused ApoE^−/− mice. ApoE^−/− mice were infused with saline or Ang II. Ang-II-infused mice were treated or not with MC-1568 (MC) or MS-275 (MS). (A) Immunohistochemical analysis of MCP-1 (left panels) and quantitative analysis of the positive-stained area (right) (n=5; scale bars: 50 μm). (B-D) mRNA levels of MCP-1 (B), COX-2 (C) and interleukin (IL)-1β (D, left panel) and IL-6 (D, right panel) normalised to GAPDH (n=8). (E) IL-6 and IL-2 systemic levels (n=6). Data are the mean±s.e.m. *P<0.05 vs saline; ^#P<0.05 vs Ang II (t-test and one-way ANOVA).