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Stereo view of a structural model of HT1 kinase. The substituted and the deleted amino acid positions in the ht1 mutants are shown as stick residues and yellow ribbons, respectively. The docked substrate analogue, AMP-PNP, is shown as a ball-and-stick model. Lys 113 is an invariant catalytic lysine in subdomain II of protein kinases that is crucial for binding to ATP.
