Table 1.

Clinical characteristics and CSF1R mutation in family with HDLS

ID	CSF1R p.E664K	Sex	Onset age	Death age	Initial symptom	Clinical features during course of disease development
						Behavioural	Dementia	Depression	Parkinsonism	Seizures
I-2	Mosaic	F	.	Alive	Healthy	None	None	None	None	None
II-1	Chimeric	F	35	Alive	Impulsivity	+	+	Not described	Not described	Not described
II-2	Heterozygous	M	56	Alive	Confusion	+++	++	+	Rigidity	+
II-3	Heterozygous	F	54	60	OCD	++	++	+++	Not described	+
II-4	Heterozygous	F	55	60	Depression	++	+	+++	+	++ (status)

OCD = obsessive compulsive disorder.