Table 3.

Pharmacokinetic parameters of ADHC after a single dosage administration to rats

Pharmacokinetic parameters	Free ADHC (3 mg/kg)	Free ADHC (9 mg/kg)	ADHC-L (3 mg/kg)
t1/2α (h)	0.08±0.04	1.33±0.18**	1.86±0.24**
t1/2β (h)	28.71±6.04	26.14±10.61	195.44±36.62**
Kel (h−1)	0.09±0.01	0.12±0.10*	0.09±0.01
CL (L/h/kg)	0.07±0.02	0.13±0.01*	0.02±0.01*
Vss (L/kg)	0.80±0.18	1.08±0.05	0.20±0.01*
MRT (h)	32.06±4.47	32.10±13.02	273.97±58.00**
AUC0–24 h (mg⋅h/L)	20.69±1.10	52.91±0.37***	106.22±1.60***
AUC0–∞ (mg⋅h/L)	42.00±12.49	67.29±1.18	163.80±24.03**

Notes: Given values are mean ± SD (n=4).

^*P<0.05

^**P<0.01

^***P<0.001 versus free ADHC (3 mg/kg) treatment.

Abbreviations: ADHC, amiodarone hydrochloride; ADHC-L, amiodarone hydrochloride-loaded liposome; AUC, area under the concentration–time curve; CL, clearance; K_el, elimination rate constant; MRT, mean residence time; SD, standard deviation; t_1/2α, half-life of distribution phase; t_1/2β, half-life of elimination phase; V_ss, steady-state distribution volume.