Table 1.

Antiviral activity of microbicides against HIV-1 and semen-exposed HIV-1 in TZM.bl cells or PBMC

Compound	Cell line	IC50		Fold IC50	IC50		Fold IC50	IC50		Fold IC50
		HIV R5	HIV R5+10% SE		HIV pTHRO	HIV pTHRO +10% SE		HIV pCH058	HIV pCH058+10% SE
G2-S16	TZM.bl PBMCs	0.040±0.025 µM 3.345±0.413 µM	8.169±4.155 µM 4.938±1.641 µM	204 1	0.089±0.013 µM	11,079±0.784 µM	125	0.886±0.806 µM	1,870±0.806 µM	2

Note: Fold increase in IC₅₀ of semen-exposed relative to nonexposed HIV-1 antiviral activity of G2-S16 against control and semen-exposed R5-HIV, pTHRO, and pCH058 in TZM.bl cells and PBMC.

Abbreviations: HIV, human immunodeficiency virus; IC₅₀, fifty percent of the effective concentration; PBMC, peripheral blood mononuclear cells; SE, semen.