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. 2016 Jan 22;48(1):e205. doi: 10.1038/emm.2015.100

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Copyright © 2016 KSBMB.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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The CB2 receptor protects striatal dopamine fibers from MPTP neurotoxicity in vivo. The STR tissues obtained from the same animals used in Figure 1 were immunostained with a TH antibody to label dopamine fibers. Control (a); MPTP (b); MPTP and WIN55,212-2 (c); MPTP and JWH-133 (d); MPTP, WIN55,212-2 and AM630 (e); and MPTP, JWH-133 and AM630 (f). (g) The optical density of TH⁺ fibers in the STR. ^***P<0.001 significantly different from controls. ^##P<0.01 and ^###P<0.001 significantly different from MPTP. ^$$P<0.01 significantly different from MPTP and WIN55,212-2; and ^&&P<0.01 significantly different from MPTP and JWH-133 (ANOVA and Student–Neuman–Keuls analysis). Scale bars: a–f, 500 μm.