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. 2016 Jan 22;48(1):e205. doi: 10.1038/emm.2015.100

Figure 5.

Figure 5

The CB2 receptor prevents MPTP-induced BBB disruption in the SN in vivo. At 3 days after the injection of vehicle as a control or of MPTP in the absence or presence of WIN55,212-2, JWH-133 and/or AM630, FITC-labeled albumin was administered to detect brain vascular permeability. Control (a); MPTP (b); MPTP and WIN55,212-2 (c); MPTP and JWH-133 (d); MPTP, WIN55,212-2 and AM630 (e); and MPTP, JWH-133 and AM630 (f). Dotted lines indicate the SNpc. Scale bars: a–l, 100 μm. (g) Bars represent the FITC-labeled-albumin-positive area in the SNpc. Four or five animals were used for each experimental group. Actual values are normalized by the value for the PBS-injected control. CON, control; M, MPTP; MW, MPTP and WIN55,212-2; MJ, MPTP and JWH-133; MWA, MPTP and WIN55,212-2 and AM630; MJA, MPTP and JWH-133 and AM630. ***P<0.001 significantly different from controls; ##P<0.01 and ###P<0.001 significantly different from MPTP only; $P<0.05 significantly different from MW; and &&P<0.01 significantly different from MJ (ANOVA and Student–Neuman–Keuls analysis).