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. 2016 Jan 29;48(1):e206. doi: 10.1038/emm.2015.102

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Copyright © 2016 KSBMB.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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CHMP5-knockdown Jurkat cells enhance the activation of AP-1 in response to TCR stimulation. (a) Control (Ctrl) and CHMP5^KD Jurkat cells were transfected with AP-1 reporter together with the Renilla luciferase vector. After 36 h, cells were stimulated for 6 h with or without anti-CD3/anti-CD28 antibodies, and a luciferase assay was performed. All error bars represent ±s.d. of the mean from triplicate samples. *P<0.05. (b, c) Ctrl and CHMP5^KD Jurkat cells were stimulated with anti-CD3/anti-CD28 for different times. Nuclear extracts were prepared and analyzed for DNA-binding activities of c-fos (b) and pho-c-Jun (c). All error bars represent ±s.d. of the mean from triplicate samples. **P<0.05.