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. 2016 Feb 19;48(2):e210. doi: 10.1038/emm.2015.116

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Copyright © 2016 KSBMB.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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2-Deoxy-D-glucose (2-DG) induces endoplasmic reticulum (ER) stress. (a) Neuroblastoma (NB) cell lines were treated with 2 mM 2-DG for 8 or 24 h, and the levels of the unfolded protein response (UPR) markers GRP78, GRP94 and C/EBP homology protein (CHOP) were then determined using western blot analysis. (b) NB cells were treated with 500 nM 17-N-allylamino-17-demethoxygeldanamycin (17-AAG), 2-DG (0.5 and 2 mM) or both, and cell viability was determined using MTS assays (n=3). *P<0.05 compared with vehicle-treated controls, ^#P<0.05 for treatment with 17-AAG+2-DG compared with treatment with 2-DG alone.