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. 2016 Mar 18;48(3):e221. doi: 10.1038/emm.2015.124

Figure 2.

Figure 2

Levels of cytokines and mediators related to inflammatory responses and T-cell function in the CIA mouse model. The levels of cytokines and inflammatory mediators in the ankles, sera and lymph nodes of the mice were measured at Day 39 by real-time reverse transcriptase–PCR and enzyme-linked immunosorbent assay. (a) mRNA levels of SIRT1, TNF-α, IL-1β, IL-6, IL-17, IL-23, IFN-γ, MCP-1, MMP-3 and MMP-13 in the ankle joints of the mSIRT1 KO (KO) and wild-type (WT) mice. (b) Comparison of the IL-6 concentrations in the sera from the mSIRT1 KO and WT mice. (c, d) mRNA levels of the cytokines and transcription factors related to T-cell differentiation in the mouse lymph nodes. The values are expressed as the means±s.e. (10 mice per group), *P<0.05, **P<0.01 vs WT.