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. 2016 Feb 26;48(2):e212. doi: 10.1038/emm.2016.1

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Copyright © 2016 KSBMB.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Effects of administration of morphine on STEP phosphorylation in dorsal striatum. Mice were injected with 20 mg kg⁻¹ morphine (intraperitoneal). After 30 min, the dorsal striatum was obtained for western blot analysis of phospho-STEP and STEP (a). Significant differences between saline-treated groups and indicated groups at *P<0.05, (n=4–6 animals per group, Student's t-test). Representative examples of neurons showing colocalization of STEP and MOR immunosignals in the dorsal striatum (b). Scale bar, 20 μm. MOR, μ-opioid receptor; NS, nonspecific.