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. 2016 Feb 26;48(2):e212. doi: 10.1038/emm.2016.1

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Copyright © 2016 KSBMB.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Morphine-induced hyperlocomotion in STEP^+/+ and STEP^C230X−/− mice. (a) Time-course changes of morphine-induced hyperlocomotion in the open field in STEP^+/+ and STEP^C230X−/− mice. Each point represents the distance that mice moved in a 10-min block. (b) Summed locomotor activity for the 120-min period after morphine administration in STEP^+/+ and STEP^C230X−/− mice. Significant difference between indicated groups at *P<0.05 and **P<0.01, respectively (n=6–8 animals per group, two-way analysis of variance followed by Bonferroni post hoc test).