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. Author manuscript; available in PMC: 2016 Jun 3.
Published in final edited form as: Nat Commun. 2012;3:1279. doi: 10.1038/ncomms2229

Figure 1. Phylogenetic and syntenic analysis of AxOct4 and AxPou2.

Figure 1

(a) Phylogenetic tree of the Oct4 and Pou2 homologues from different species based on the alignment of the POU sequences indicates that axolotl has both the Pou2 and Oct4 homologues. The branches are shown with their calculated relative lengths and the posterior probabilities are labelled at the corresponding nodes. The outgroup (BRN3C), the Oct1 and Oct6 sequences and the dotted branches are shown to emphasize the split of the subtree of the Oct4/Pou2 sequences. The length of the dotted branches is arbitrary. See Supplementary Fig. S1 for sequence alignment. (b) Assignment of AxPou2 and AxOct4 to Ambystoma linkage group 16 and 17, respectively. AxPou2 mapped to the position of AxNpdc1 (20 cM) and AxOct4 (76 cM) mapped to the position of AxTcf19 and AxCchrc1. The Pou2-Npdc1 and Oct4-TCf19-Cchcr1 linkage relationships are observed as conserved syntenies in chicken–zebrafish and mouse–human, respectively.