Table 3.

Association of creatinine-corrected log₁₀ prenatal OP metabolite levels and 24-month MDI and PDI considering heterogeneity by center.

Model	CHAMACOS [β per 10-fold increase (95% CI)]a	HOME [β per 10-fold increase (95% CI)]a	Columbia [β per 10-fold increase (95% CI)]a	Mount Sinai [β per 10-fold increase (95% CI)]a	Center-OP-interaction (p-value)a	Pooled [β per 10-fold increase (95% CI)]a	Pooled (extended model) [β per 10-fold increase (95% CI)]b
24-month MDI	n = 366	n = 257	n = 53	n = 225	n = 901	n = 901	n = 890
Log10 ∑DAP (nmol/gC)	–4.17 (–7.00, –1.33)	0.97 (–1.82, 3.76)	–0.79 (–4.17, 2.59)	–1.14 (–3.12, 0.84)	0.09	–1.28 (–2.58, 0.03)	–1.48 (–2.77, –0.19)
Log10 ∑DEP (nmol/gC)	–1.40 (–4.12, 1.32)	–1.10 (–3.42, 1.22)	0.11 (–2.88, 3.11)	–0.22 (–1.85, 1.42)	0.81	–0.57 (–1.69, 0.54)	–0.82 (–1.93, 0.28)
Log10 ∑DMP (nmol/gC)	–3.64 (–5.97, –1.32)	0.73 (–1.59, 3.04)	0.13 (–2.33, 2.58)	–0.80 (–2.52, 0.91)	0.05	–0.91 (–1.98, 0.16)	–1.06 (–2.12, 0.00)
24-month PDI	n = 368	n = 258	n = 55	n = 228	n = 909	n = 909	n = 898
Log10 ∑DAP (nmol/gC)	–1.35 (–4.10, 1.41)	1.09 (–1.63, 3.80)	–0.39 (–3.67, 2.90)	–0.27 (–2.17, 1.63)	0.67	–0.23 (–1.48, 1.03)	–0.08 (–1.34, 1.18)
Log10 ∑DEP (nmol/gC)	–0.91 (–3.54, 1.72)	–0.32 (–2.57, 1.93)	–0.35 (–3.13, 2.42)	0.52 (–1.03, 2.06)	0.79	–0.02 (–1.09, 1.04)	0.15 (–0.91, 1.22)
Log10 ∑DMP (nmol/gC)	–1.29 (–3.56, 0.97)	0.83 (–1.41, 3.08)	–0.42 (–2.79, 1.95)	–0.45 (–2.11, 1.21)	0.63	–0.35 (–1.39, 0.68)	–0.30 (–1.34, 0.73)
∑DAP = ∑DEP + ∑DMP. aModels were adjusted for maternal education, marital status, and age at delivery, alcohol use during pregnancy, child sex, Home environment score quartile, and breastfeeding at least 3 months after birth, and include metabolite × center interaction terms. Tests for interaction were calculated using F-tests with 3 degrees of freedom. bAdditionally adjusted for race/ethnicity, smoking and drug use during pregnancy.