Table 4.
Cox multivariate analysis of EFS and OS in all patients.
| Prognostic Factor | Hazard Ratio | 95% CI | P |
|---|---|---|---|
| Affecting event-free survival (EFS) | |||
| Age, years | 0.02 | ||
| < 3 | 1 | --- | |
| 3 to 6 | 0.55 | 0.37–0.83 | |
| >=6 | 0.68 | 0.43–1.06 | |
| Residual tumor | 0.05 | ||
| < = 1.5 cm2 | 1 | --- | |
| 1.5–3.0 cm2 | 1.47 | 0.66–3.27 | |
| >3 cm2 | 2.25 | 1.08–4.69 | |
| Unknown | 1.64 | 0.71–3.78 | |
| NF1 status | <0.001 | ||
| NF1 | 1 | --- | |
| Non-NF1 | 2.45 | 1.64–3.66 | |
| Affecting overall survival (OS) | |||
| Sex | 0.05 | ||
| Male | 1 | --- | |
| Female | 2.33 | 0.99–5.51 | |
| Age, years | 0.04 | ||
| < 3 | 1 | --- | |
| 3–6 | 0.29 | 0.094–0.88 | |
| >= 6 | 0.35 | 0.12–1.03 | |
| Residual tumor | 0.02 | ||
| <=1.5 cm2 | 1 | --- | |
| 1.5–3.0 cm2 | 0.17 | 0.01–2.04 | |
| >3.0 cm2 | 1.78 | 0.36–8.73 | |
| Unknown | 0.86 | 0.15–5.06 | |
| Institutional path | 0.01 | ||
| Pilocytic astrocytoma | 1 | --- | |
| LG fibrillary astrocytoma | 3.83 | 0.91–16.17 | |
| LG astrocytoma, NOS | 1.33 | 0.30–6.0 | |
| Other eligible diagnoses | 16.20 | 2.87–91.25 | |
| No surgery/insufficient | 0.78 | 0.25–2.40 | |
| Tumor site | 0.02 | ||
| Optic chiasm/hypothalamic | 1 | --- | |
| Thalamus | 5.64 | 1.42–22.42 | |
| Other supratentorial | 0.35 | 0.06–2.06 | |
| Posterior fossa/brainstem | 0.47 | 0.06–3.86 | |
| Spinal cord | 3.69 | 0.37–37.12 | |