Table 1.

Characteristics of Study Samples

	Breast cancer family*	Ovarian cancer family†	Total‡
Number of families	155	36	176*
Number of families with BRCA1 mutation	94	29	113
Number of families with BRCA2 mutation	61	7	63
Number of family members with breast cancer	579	74	587
Predicted number of mutation carriers in breast cancer patients	469.1	60.5	477.1
Number of family members with ovarian cancer	59	81	105
Predicted number of mutation carriers in ovarian cancer patients	56.5	77.7	111.3
Probands with breast cancer	96	12	100
Probands with ovarian cancer	10	8	14
Probands with breast and ovarian cancer	7	3	8

^*at least two family members diagnosed with breast cancer in consecutive generations;

^†at least two family members diagnosed with ovarian cancer in consecutive generations.

^‡15 families were included as both breast and ovarian cancer families, so the numbers cannot be added up.