Table 1. Selected up-regulated or down-regulated genes in pulpitis patients.
| Gene Symbol | Pulpitis vs Normal | None to Mild vs Moderate to Severe Pain | Gene Function (genecards.org) |
|---|---|---|---|
| AMELX | Enamel biomineralization | ||
| CALCRL | Bone metabolism | ||
| CCL20 | Chemotaxis | ||
| CD14 | Innate immune response | ||
| CD163 | Acute phase receptor | ||
| CD79A | B-cell receptor function | ||
| COL10A1 | Collagen formation | ||
| COL11A2 | Collagen formation | ||
| COL12A1 | Collagen formation | ||
| COL14A1 | Collagen formation | ||
| COL15A1 | Collagen formation | ||
| COL15A1 | Collagen formation | ||
| COL18A1 | Collagen formation | ||
| COL1A1 | Collagen formation | ||
| COL1A2 | Collagen formation | ||
| COL21A1 | Collagen formation | ||
| COL4A1 | Collagen formation | ||
| COL4A2 | Collagen formation | ||
| CXCL3 | Chemotaxis | ||
| DEFA1B/1A | Antimicrobial activity | ||
| DEFA3 | Antimicrobial activity | ||
| DSPP | Dentin formation | ||
| IL10RA | IL-10 signaling | ||
| IL1A | Inflammatory response | ||
| IL1B | Inflammatory response | ||
| IL6 | Inflammation, B-cell maturation | ||
| IL8 | Chemotaxis | ||
| LBP | Innate immune response | ||
| MMP13 | Collagen degradation | ||
| MMP20 | Amelogenin degradation | ||
| MMP9 | Collagen degradation | ||
| NOD2 | Innate immune response | ||
| NR5A2 | Antiviral activity | ||
| PTGS2 | Prostaglandin formation | ||
| SCN8A | Sodium ion permeability | ||
| TLR1 | Innate immune response | ||
| TLR2 | Innate immune response | ||
| TLR3 | Innate immune response | ||
| TLR4 | Innate immune response | ||
| TLR6 | Innate immune response | ||
| TLR8 | Innate immune response | ||
| TLR9 | Innate immune response | ||
| TNFA | Inflammatory response |
Downregulated
Upregulated
No difference
Fold change: Downregulated ≤0.5; Upregulated: ≥1.5; q<0.05