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. Author manuscript; available in PMC: 2017 Jun 2.
Published in final edited form as: Cell. 2016 May 12;165(6):1401–1415. doi: 10.1016/j.cell.2016.04.033

Figure 7. Increased expression of LIN28B and let-7 target genes correlates with poor survival in PDAC.

Figure 7

A, Kaplan–Meier analysis of the indicated PDAC patient samples based on LIN28B IHC score (n=120). B–C, Gene Set Enrichment Analysis (GSEA) plots showing that human PDAC tumors (B) and PDAC cell lines from the Cancer Cell line Encyclopedia (CCLE) (C) with high levels of LIN28B (LIN28Bhigh) overexpress many of the genes that are regulated by let-7. D, GSEA plots showing that human LIN28Bhigh PDAC tumors overexpress targets of let-7 which are oncofetal genes. E, Correlation of HMGA2 and IGF2BP3 RNA expression in human PDAC samples from the TCGA pancreatic cancer dataset. F, Kaplan-Meier survival curves based on expression of HMGA2 (left) and IGF2BP3 (right) in human pancreatic cancer datasets from the TCGA. G, Model for SIRT6 loss in PDAC pathogenesis. * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001. See also Fig S7.