Table 1.

Dose allocation decision based on the posterior probability at two candidate doses d_j and d_j+1. Target probability is Γ = 0.25. The observed toxicity rate at d_j is less than Γ and the observed toxicity rate at d_j+1 is higher than Γ. Data at each dose is the number of DLTs over the number of patients assigned to the dose. The entry 0/1:3, for example, indicates one of the three possibilities: 0 DLTs were observed out of 1 or 2 or 3 patients.

Observed data at dj	Observed data at dj+1	Decision
1/4:9, 2/8:12, 3/12	1/3, 2/5	Lower Dose
1/4:10, 2/8:12, 3/12	3/7, 5/12	Lower Dose
2/8:12, 3/12	2/7, 3/9, 4/11	Lower Dose
1/4:7, 2/8:12, 3/12	3/8	Lower Dose
1/5:6, 2/8:12, 3/12	2/6	Lower Dose
2/9:10, 3/12	3/10	Lower Dose
3/12	3/11	Lower Dose
1/4:8, 2/8:12, 3/12	4/10	Lower Dose
2/8:11, 3/12	4/12	Lower Dose
1/4:11, 2/8:12, 3/12	4/9	Lower Dose
0/1:2, 1/4:12, 2/8:12, 3/12	1/2, 2/4, 5/11	Lower Dose
0/1:3, 1/4:12, 2/8:12, 3/12	3/6	Lower Dose
0/1:4, 1/4:12, 2/8:12, 3/12	4/8	Lower Dose
0/1:5, 1/4:12, 2/8:12, 3/12	5/10, 6/12	Lower Dose
0/1:8, 1/4:12, 2/8:12, 3/12	6/11	Lower Dose
0/3:12	1/2, 2/4, 5/11	Higher Dose
0/4:12	3/6	Higher Dose
0/5:12	4/8	Higher Dose
0/2:12, 1/10:12	1/3, 2/5	Higher Dose
0/2:12, 1/11:12	3/7, 5/12	Higher Dose
0/2:12, 1/4:12	2/6:7, 3/9, 4/11	Higher Dose
0/1:12, 1/8:12	3/8, 4/10	Higher Dose
0/1:12, 1/4:12, 2/8:12	3/10:11	Higher Dose
0/1:12, 1/4:12, 2/12	4/12	Higher Dose
0/1:12, 1/12	4/9	Higher Dose
0/6:12	5/10, 6/12	Higher Dose
0/9:12	6/11	Higher Dose