Table 3.

Proportion of trials each dose was recommended. All designs except the CRM were simulated with addition of the safety rule. The CRM with the safety rule is denoted by the CRM+S. The target DLT probability is 0.20 and the total sample size is n = 30. Numbers at the true MTD are in bold.

	d1	d2	d3	d4	d5	d6
Scenario 1	0.05	0.10	0.20	0.30	0.50	0.70
mTPI	0.05	0.26	0.41	0.24	0.03	0.00
RED	0.05	0.20	0.39	0.33	0.04	0.00
t-statistics	0.05	0.26	0.44	0.22	0.02	0.00
CRM+S	0.05	0.28	0.46	0.20	0.00	0.00
CRM	0.01	0.19	0.52	0.28	0.01	0.00
Scenario 2	0.01	0.05	0.50	0.60	0.70	0.80
mTPI	0.01	0.93	0.06	0.00	0.00	0.00
RED	0.01	0.94	0.05	0.00	0.00	0.00
t-statistics	0.01	0.93	0.06	0.00	0.00	0.00
CRM+S	0.01	0.87	0.10	0.02	0.00	0.00
CRM	0.00	0.66	0.34	0.00	0.00	0.00
Scenario 3	0.05	0.06	0.08	0.11	0.19	0.34
mTPI	0.02	0.05	0.10	0.22	0.42	0.19
RED	0.02	0.02	0.05	0.19	0.44	0.27
t-statistics	0.02	0.05	0.13	0.28	0.37	0.14
CRM+S	0.01	0.04	0.12	0.33	0.46	0.04
CRM	0.00	0.01	0.06	0.31	0.56	0.05
Scenario 4	0.06	0.08	0.12	0.18	0.40	0.71
mTPI	0.04	0.10	0.22	0.46	0.15	0.00
RED	0.03	0.06	0.16	0.55	0.19	0.00
t-statistics	0.05	0.11	0.27	0.47	0.11	0.00
CRM+S	0.02	0.10	0.28	0.54	0.06	0.00
CRM	0.00	0.04	0.21	0.64	0.10	0.00
Scenario 5	0.00	0.00	0.03	0.05	0.11	0.22
mTPI	0.00	0.00	0.01	0.06	0.32	0.60
RED	0.00	0.00	0.01	0.04	0.28	0.66
t-statistics	0.00	0.00	0.01	0.09	0.37	0.53
CRM+S	0.00	0.00	0.02	0.14	0.58	0.27
CRM	0.00	0.00	0.00	0.05	0.63	0.32