Table 4.

Association between NIT Result and the Primary Composite Outcome by Sex and NIT Type

	Event Rate No. of Events/Sample Size (%)		Positive vs. Negative Unadjusted*		Positive vs. Negative Adjusted†
Sex/NIT Type	Positive Test	Negative Test	Hazard Ratio (95% CI)	P-value	Hazard Ratio (95% CI)	P-value
Interaction between test result, test type, and sex			---	0.020	---	0.010
Women
Association of test positivity in women randomized to CTA	18/184 (9.78%)	39/2148 (1.82%)	6.39 (3.65-11.17)	<0.001	5.86 (3.32-10.35)	<0.001
Association of test positivity in women randomized to stress test	14/274 (5.11%)	41/2114 (1.94%)	2.70 (1.45-5.03)	0.002	2.27 (1.21-4.25)	0.011
Difference between the association in CTA and the association in stress test			---	0.043	---	0.028
Men
Association of test positivity in men randomized to CTA	31/350 (8.86%)	49/1818 (2.70%)	3.69 (2.35-5.79)	<0.001	2.80 (1.76-4.45)	<0.001
Association of test positivity in men randomized to stress test	33/290 (11.38%)	40/1788 (2.24%)	5.39 (3.39-8.56)	<0.001	4.42 (2.77-7.07)	<0.001
Difference between the association in CTA and the association in stress test			---	0.249	---	0.168

CTA = computed tomographic angiography; NIT = noninvasive test.

^*Unadjusted models contained test result, randomized testing arm, sex, and all 2-way and 3-way interaction terms.

^†Adjusted for age, race, body mass index, coronary artery disease (CAD) equivalent, Framingham risk score (12), ASCVD score (13), 2011 Diamond and Forrester score (14), hypertension, dyslipidemia, diabetes, family history of premature CAD, sedentary lifestyle, smoking, typicality of chest pain, and physician's estimation of likelihood of significant CAD.