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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Stem Cells. 2016 Mar 15;34(6):1626–1636. doi: 10.1002/stem.2307

Figure 2. BVES regulates intestinal stem cell dynamics in vivo.

Figure 2

(A) qRT-PCR analysis revealed increased expression of (A) Axin2 (*P<0.05, n=12) and (B) Lgr5 (*P<0.05, n=12) but no significant difference in mRNA levels of (C) Lrig1 (P=0.21, n=12) and Bmi1 (P=0.41, n=12) in Bves−/− proximal small intestine compared to WT. (D) Intercross of WT and Bves−/− mice with Lgr5-EGFP-ires-CreERT2 mice revealed increased number of GFP+ cells/+crypt (3.5 vs. 5.2, **P<0.01, n=16) in the Bves−/− cohort. Images were captured at 400× magnification.