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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Stem Cells. 2016 Mar 15;34(6):1626–1636. doi: 10.1002/stem.2307

Figure 5. Bves−/− enteroids are hyper-responsive to Wnt activation.

Figure 5

(A) Bves−/− enteroids were hyper-responsive to Wnt activation, with a significantly higher percentage of cystic enteroids present on days 1–5 post-plating after Wnt3a addition to growth factor media. Representative images of enteroids on day 6 post-plating are shown below at 40× (left) and 100× (right) magnification. Cystic structures are marked by arrowheads. (B) No significant differences were observed in WT and Bves−/− enteroid viability on any given day post-plating with R-spondin growth factor depletion. *P<0.05, **P<0.01 (n=6).