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. 2015 Dec 14;44:2145–2157. doi: 10.1007/s10439-015-1520-3

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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The graph shows the load vs. time curves from the mechanical assay. The test was conducted after 5 weeks long in vitro experiment on 3D calcite scaffolds without cells (a) and calcite scaffolds seeded with HBDCs (b). A characteristic feature of 3D calcite samples is charting a sharp decline in stress at the time of their destruction. The samples disintegrate completely (a). Scaffolds seeded with cells (b) behave differently. Characteristic property of these samples is that after reaching the maximum stress the decrease is gradual which is typical for composites and not for brittle materials.