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. 2016 Mar 18;101(6):514–515. doi: 10.1136/archdischild-2015-309579

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Hypophosphatasia (HPP) diagnostic pathway. This pathway focuses on presentation and diagnosis of infants and children with HPP. *Radiological findings can include profound hypomineralisation, irregularity of the provisional zone of calcification, physeal widening, metaphyseal flaring/fraying, metaphyseal radiolucencies and fractures.¹ ³ ALP, alkaline phosphatase; PEA, phosphoethanolamine; PLP, pyridoxal 5′-phosphate; PPi, inorganic pyrophosphate.