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. 2015 Mar 11;65(6):935–943. doi: 10.1136/gutjnl-2014-308323

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MyD88^IEC-KO/TRIF^IEC-KO mice are not more susceptible to dextran sodium sulfate (DSS)-induced acute colitis. (A) Body weight change, (B) rectal bleeding score, and (C) diarrhoea score of TRAF6^FL (n=8), TRAF6^IEC-KO (n=8), MyD88^FL/TRIF^FL (n=7) and MyD88^IEC-KO/TRIF^IEC-KO (n=6) mice administered 1% DSS for 7 days followed by 2 days of normal drinking water. For A–C, asterisks indicate statistically significant differences between TRAF6^FL and TRAF6^IEC-KO mice. (D) Colon length, (E) histological tissue damage and inflammation scoring and (F) representative H&E stained colon cross-sections of indicated mice at day 9 of the DSS colitis protocol. Bars, 100 μm. All data shown are representative of two independent experiments. All statistical analyses were performed with unpaired two-sided Student's t tests with unequal variance.