Table 1.
Baseline characteristics by % predicted FEV1 in 3242 men with no prior heart failure or myocardial infarction
| % predicted FEV1 | ||||||
|---|---|---|---|---|---|---|
| ≤5th percentile | 6–24th percentile | 25–49th percentile | 50–74th percentile | ≥75th percentile | p Difference between groups | |
| No. of men | 162 | 651 | 810 | 813 | 806 | |
| Range FEV1, % predicted | <48.4 | 48.4–75.0 | 75.1–89.0 | 89.1–101.6 | ≥101.7 | |
| FEV (L) | 1.12 (0.26) | 1.92 (0.31) | 2.49 (0.31) | 2.86 (0.34) | 3.33 (0.47) | |
| FVC (L) | 2.12 (0.09) | 2.77 (0.06) | 3.27 (0.06) | 3.64 (0.06) | 4.13 (0.07) | |
| % FEV1/FVC<0.7 | 33.3 | 34.1 | 30.3 | 26.8 | 21.1 | |
| Categorical variables (%) | ||||||
| Smokers | 27.2 | 21.4 | 13.8 | 8.5 | 4.7 | <0.001 |
| Manual | 63.6 | 62.5 | 54.0 | 51.3 | 45.8 | <0.001 |
| Inactive | 54.4 | 39.0 | 31.6 | 30.8 | 26.2 | <0.001 |
| Heavy drinkers | 6.2 | 5.2 | 3.2 | 4.2 | 3.0 | 0.083 |
| Diabetes | 14.8 | 16.0 | 12.4 | 10.8 | 10.4 | 0.001 |
| Stroke | 6.8 | 5.5 | 5.1 | 2.8 | 3.4 | 0.017 |
| AF | 3.7 | 3.5 | 3.5 | 2.8 | 2.4 | 0.620 |
| Antihypertensive use | 33.3 | 34.1 | 30.3 | 26.8 | 21.1 | <0.001 |
| Left ventricular hypertrophy | 5.6 | 6.3 | 7.3 | 8.9 | 8.2 | 0.302 |
| Continuous variables (means) | ||||||
| Age (years) | 69.4 (5.4) | 69.1 (5.4) | 68.0 (5.2) | 67.8 (5.5) | 68.9 (5.7) | <0.001 |
| BMI (kg/m2) | 25.5 (3.9) | 27.1 (4.0) | 27.1 (3.7) | 26.9 (3.3) | 26.4 (3.2) | <0.001 |
| Systolic blood pressure (mm Hg) | 147.8 (21.9) | 151.5 (25.4) | 149.2 (23.5) | 150.8 (24.1) | 148.7 (22.9) | 0.090 |
| Cholesterol (mmol/L) | 5.86 (1.10) | 5.93 (1.02) | 6.10 (1.10) | 6.09 (1.04) | 6.09 (1.06) | 0.002 |
| High-density lipoprotein-cholesterol (mmol/L) | 1.41 (0.41) | 1.31 (0.35) | 1.32 (0.34) | 1.31 (0.33) | 1.36 (0.33) | 0.002 |
| C-reactive protein (mg/L)* | 4.48 (1.30–6.01) | 2.27 (1.08–4.82) | 1.82 (0.90–3.47) | 1.38 (0.73–2.87) | 1.23 (0.60–2.40) | <0.001 |
| N-terminal pro-brain natriuretic peptide (pg/mL)* | 115.6 (55–257) | 108.9 (49–220) | 86.5 (44–160) | 77.5 (38–147) | 80.6 (41–146) | <0.001 |
| Cardiac troponin T (pg/mL)* | 13.7 (10.1–18.9) | 12.4 (9.3–16.4) | 11.2 (8.6–15.9) | 11.0 (8.5–14.8) | 11.0 (8.2–14.7) | <0.001 |
Mean and SD unless specified.
*Geometric mean and IQR.