Table 3.
Adjusted HR (95% CIs) for incident heart failure (HF) in relation to % predicted FEV1 and % predicted FVC in men with no prior HF or myocardial infarction
| Abnormal (≤5th percentile) | 6–24th percentile | 25–49th percentile | 50–74th percentile | ≥75th percentile | p Trend | |
|---|---|---|---|---|---|---|
| % predicted FEV | ||||||
| No. of men | 162 | 651 | 810 | 813 | 806 | |
| Rate/1000 (n) | 10.1 (14) | 9.4 (60) | 5.7 (49) | 5.9 (52) | 4.0 (36) | |
| Age-adjusted | 2.76 (1.49 to 5.12) | 2.44 (1.61 to 3.69) | 1.59 (1.03 to 2.45) | 1.64 (1.07 to 2.51) | 1.00 | <0.001 |
| Model 1 | 2.19 (1.14 to 4.21) | 1.96 (1.27 to 3.02) | 1.34 (0.89 to 2.08) | 1.45 (0.94 to 2.23) | 1.00 | 0.002 |
| Model 2 | 2.10 (1.10 to 4.05) | 1.91 (1.24 to 2.94) | 1.31 (0.84 to 2.03) | 1.43 (0.93 to 2.19) | 1.00 | 0.004 |
| Model 3 | 1.87 (0.97 to 3.60) | 1.70 (1.10 to 2.63) | 1.25 (0.80 to 1.93) | 1.36 (0.89 to 2.10) | 1.00 | 0.016 |
| Model 4 | 1.78 (0.93 to 3.44) | 1.72 (1.11 to 2.65) | 1.18 (0.76 to 1.84) | 1.41 (0.92 to 2.13) | 1.00 | 0.024 |
| Model 5 | 1.63 (0.84 to 3.19) | 1.61 (1.04 to 2.49) | 1.17 (0.75 to 1.82) | 1.35 (0.88 to 2.07) | 1.00 | 0.047 |
| % predicted FVC | ||||||
| No. of men | 164 | 649 | 813 | 807 | 811 | |
| Rate/1000 (n) | 11.3 (16) | 8.8 (56) | 6.4 (56) | 4.5 (38) | 4.9 (45) | |
| Age-adjusted | 2.29 (1.37 to 4.18) | 1.80 (1.22 to 2.67) | 1.38 (0.93 to 2.04) | 0.91 (0.59 to 1.40) | 1.00 | <0.001 |
| Model 1 | 1.78 (0.98 to 3.22) | 1.33 (0.88 to 2.00) | 1.14 (0.77 to 1.70) | 0.80 (0.52 to 1.23) | 1.00 | 0.083 |
| Model 2 | 1.68 (0.92 to 3.05) | 1.30 (0.86 to 1.96) | 1.13 (0.76 to 1.68) | 0.79 (0.31 to 1.22) | 1.00 | 0.121 |
| Model 3 | 1.50 (0.82 to 2.75) | 1.33 (0.88 to 2.00) | 1.11 (0.74 to 1.65) | 0.84 (0.55 to 1.31) | 1.00 | 0.213 |
| Model 4 | 1.46 (0.80 to 2.67) | 1.18 (0.79 to 1.78) | 1.07 (0.71 to 1.59) | 0.77 (0.50 to 1.20) | 1.00 | 0.386 |
| Model 5 | 1.29 (0.69 to 2.39) | 1.25 (0.83 to 1.88) | 1.07 (0.72 to 1.60) | 0.83 (0.53 to 1.20) | 1.00 | 0.453 |
Model 1=adjusted for age, smoking status, physical activity, heavy drinking, social class, body mass index, left ventricular hypertrophy, systolic blood pressure, use of antihypertensive drugs, diabetes, stroke and atrial fibrillation.
Model 2=model 1+ C-reactive protein.
Model 3=model 2+ N-terminal pro-brain natriuretic peptide (NT-proBNP ).Model 4=model 2+ cardiac troponin T (cTnT).
Model 5=model 2+NT-proBNP+cTnT.