Table 4.

Mean lung function and the difference in mean level of log N terminal pro-brain natriuretic peptide (NT-proBNP) and log cardiac troponin T (cTnT) in men with restrictive and obstructive lung patterns compared with men with normal lung pattern in men with no prior heart failure or myocardial infarction

			Obstructive
	Normal	Restrictive	Mild	Moderate	Severe
	N=1582	N=887	N=235	N=351	N=137
Mean FEV1,% predicted	101	75	95	66	39
Range, %	74–193	15–106	88–219	55–122	29–125
Mean FEV1(SD), L	3.04 (0.48)	2.25 (0.49)	2.80 (0.53)	1.96 (0.34)	1.14 (0.27)
Mean FVC, % Predicted	96	67	101	83	61
Range, %	80–156	12–79	88–219	55–122	29–125
Mean FVC (SD), L	3.82 (0.59)	2.67 (0.56)	4.32 (0.80)	3.25 (0.61)	2.39 (0.83)
		Mean difference (95% CI) in log NT-proBNP (pg/mL)
Age-adjusted	0	0.16 (0.08 to 0.24)*	−0.03 (−0.17 to 0.11)	0.20 (0.19 to 0.11)*	0.21 (0.04 to 0.39)*
Model 1	0	0.12 (0.04 to 0.20)*	−0.05 (−0.17 to 0.08)	0.16 (0.05 to 0.27)*	0.17 (0.01 to 0.32)*
Model 2	0	0.08 (0.003 to 0.16)*	−0.06 (−0.19 to 0.07)	0.11 (0.002 to 0.22)*	0.08 (−0.09 to 0.25)
		Mean difference (95% CI) in log cTnT (pg/mL))
Age-adjusted	0	0.10 (0.07 to 0.14)*	−0.02 (−0.08 to 0.37)	0.00 (−0.05 to 0.05)	0.11 (0.04 to 0.19)*
Model 1	0	0.08 (0.06 to 0.10)*	−0.02 (−0.08 to 0.04)	−0.01 (−0.05 to 0.04)	0.11 (0.04 to 0.19)*
Model 2	0	0.07 (0.05 to 0.09)*	−0.02 (−0.08 to 0.04)	−0.01 (−0.06 to 0.04)	0.08 (0.004 to 0.16)*

Normal used as the reference group.

Model 1=adjusted for age, smoking status, physical activity, heavy drinking, social class, body mass index, left ventricular hypertrophy, systolic blood pressure, use of antihypertensive drugs, diabetes, stroke and atrial fibrillation.

Model 2=model 1+ C-reactive protein.

*Significantly different from the normal group (p<0.05); normal=FEV1/FVC≥0.70 and FVC≥80% and not on bronchodilators.