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. 2016 Jan 5;87(6):580–588. doi: 10.1136/jnnp-2015-311945

Figure 2.

Figure 2

White Matter Pathology. Regions of significant difference in (A) FA and (B) RD between patients with ALS and controls (ie, significance masks) in a TBSS analysis encompassing the major tracts shown to be involved in ALS—the corpus callosum, the CST bilaterally, and the SLF bilaterally. (B, C, D, E, F) illustrate, in each tract, the differences in FA (within the significance masks comparing patients with ALS to controls) across the three participant groups. (H, I, J, K, L) illustrate, in each tract, the differences in RD (within the significance masks comparing patients with ALS to controls) across the three participant groups. ALS, amyotrophic lateral sclerosis; CST, corticospinal tracts; FA, fractional anisotropy; SLF, superior longitudinal fasciculus; RD, radial diffusivity; TBSS, tract-based spatial statistics.