Table 2.

Change in Primary and Secondary Outcome Variables in VINDICATE at 12 Months Post-Randomization: Intention-to-Treat Population

Endpoint	Randomized Treatment	Mean Change After 12 Months	ANCOVA Difference in Mean Change	p Value
Primary outcome
6-min walk distance, m	Placebo	10.10 (-20.77 to 40.96)	-24.11 (-65.81 to 17.60)	0.255
	Vitamin D	-12.56 (-40.80 to 15.68)
Secondary outcomes
LVEF, %	Placebo	1.36 (-0.38 to 3.11)	6.07 (3.20 to 8.94)	<0.001
	Vitamin D	7.65 (5.21 to 10.09)
LVEDD, mm	Placebo	-0.08 (-1.25 to 1.10)	-2.49 (-4.09 to -0.90)	0.002
	Vitamin D	-2.45 (-3.70 to -1.21)
LVESD, mm	Placebo	-0.99 (-2.31 to 0.33)	-2.09 (-4.11 to -0.06)	0.043
	Vitamin D	-2.72 (-4.52 to -0.92)
LVEDV, ml	Placebo	-3.83 (-13.36 to 5.70)	-13.11 (-25.63 to -0.60)	0.040
	Vitamin D	-16.47 (-25.71 to -7.22)
LVESV, ml	Placebo	-8.49 (-17.98 to 1.01)	-12.65 (-24.76 to -0.54)	0.041
	Vitamin D	-18.77 (-25.96 to -9.59)

Values are mean change (95% confidence intervals); 95% significance shown in bold.

ANCOVA = analysis of covariance; other abbreviations as in Table 1.