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. 2016 Jun 1;90(5):1000–1015. doi: 10.1016/j.neuron.2016.04.046

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© 2016 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Dynein Accumulates in the Growth Cone Coincident with Axon Specification

(A) Still images from Movie S1 showing neurite outgrowth in dynein-GFP stage 2 neuron. Filled arrowhead, neurite with highest dynein-GFP intensity; empty arrowheads, other neurites. Long arrow shows direction of axon exit. Time stamps, hours:minutes; fluorescence intensity scale, bottom left.

(B) Maximum projection of Movie S1 with neurite labeling used in (C).

(C) Individual neurite integrated density as a percentage of the total in all neurites from Movie S1 through time. Neurites labeled as in (B).

(D) Maximum projection of Movie S2, dynein-GFP neuron transfected with K560-Halo, indicating neurite labeling for (E) and (F).

(E) Still images of Neurite 2 (see D) through time. Quantification bars show relative integrated density of K560 (orange) and dynein-GFP (green) within Neurite 2 over time.

(F) Individual neurite integrated density as a percentage of the total in all neurites from Movie S2 through time. Neurites labeled as in (D). See also Figure S2.