TABLE 1.
Baseline Characteristics
| SYNTAX Score | |||||
|---|---|---|---|---|---|
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| Variables | Total (N = 353) | Low (0–22) (n = 289) | Intermediate (23–32) (n = 40) | High (≥33) (n = 24) | p Value |
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| Age, yrs | 65.0 ± 11.0 | 64.0 ± 11.0 | 67.0 ± 9.0 | 68.0 ± 10.0 | 0.02 |
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| Male | 79.0 | 78.0 | 88.0 | 75.0 | 0.35 |
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| BMI, kg/m2 | 29.4 (26.4–33.4) | 29.0 (29.3–30.6) | 30.2 (28.9–32.9) | 32.7 (29.2–34.7) | 0.22 |
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| Systolic BP, mm Hg | 128.8 ± 19.4 | 128.6 ± 18.8 | 125.1 ± 21.9 | 137.4 ± 21.9 | 0.06 |
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| Diabetes mellitus | 30.3 | 26.0 | 47.5 | 54.2 | 0.001 |
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| Hypertension | 80.5 | 77.5 | 92.5 | 95.8 | 0.012 |
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| Current smoker | 60.2 | 59.9 | 60.0 | 65.2 | 0.40 |
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| Unprotected left main CAD | 5.7 | 1.7 | 22.5 | 25 | <0.001 |
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| LDL cholesterol, mg/dl | 81 (63–104) | 82.0 (64.0–105.0) | 70.0 (51.0–85.0) | 78.0 (62.0–103.0) | 0.03 |
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| HDL cholesterol, mg/dl | 45.0 (36–55) | 45.0 (37.0–55.0) | 43.0 (30.0–59.0) | 42.0 (35.0–49.0) | 0.26 |
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| Triglyceride, mg/dl | 123.0 (84–159) | 119.0 (84.0–154.0) | 146 (92.0–215.0) | 142.0 (88.0–178.0) | 0.09 |
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| eGFR, ml/min/1.73 m2 | 95.33 (72.5–116.1) | 97.44 (75.4–115.6) | 85.68 (54.4–123.1) | 79.78 (59.9–114.3) | 0.004 |
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| Medication: | |||||
| Aspirin | 74.0 | 64.0 | 75.0 | 75.0 | 0.98 |
| ACEI or ARB | 36.0 | 44.0 | 68.0 | 42.0 | <0.001 |
| Statin | 66.0 | 70.0 | 70.0 | 50.0 | 0.203 |
| Beta-blocker | 58.0 | 68.0 | 62.0 | 58.0 | 0.79 |
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| TMAO, μM | 5.48 (3.41–9.76) | 4.84 (3.1–7.5) | 12.02 (7.66–15.34) | 19.69 (16.1–26.28) | <0.001 |
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| hs-cTnT, ng/l | 10.41 (7.03–18.04) | 9.73 (6.86–15.83) | 16.82 (9.74–27.65) | 12.39 (8.49–28.78) | 0.003 |
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| Diffuse lesion characteristics | 20.7 | 17.0 | 32.5 | 45.8 | <0.001 |
Values are mean ± SD, %, or median (interquartile range).
ACEI = angiotensin-converting enzyme inhibitors; ARB = angiotensin receptor blocker; BMI = body mass index; BP = blood pressure; eGFR = estimated glomerular filtration rate; HDL = high-density lipoprotein; hs-cTnT = high-sensitivity cardiac troponin T; LDL = low-density lipoprotein; SYNTAX = SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery; TMAO = trimethylamine N-oxide.