Table 3.

Tissue specification for gene expression changes

Fold change Tissue	Initial Evaluation (D1)				Follow-Up Evaluation (D2)
	1.3		1.5		1.3		1.5
	n	P	n	P	n	P	n	P
Whole brain	154	1.8E-32	27	3.2E-8	750	4.4E-202	116	2.0E-38
Trigeminal ganglion	51	7.3E-7			136	4.9E-3	23	3.9E-2
Superior cervical ganglion	163	8.0E-7	25	5.7E-2	604	1.2E-3	90	1.5E-2
Medulla oblongata	87	5.7E-4			312	1.3E-2
Amygdala	80	8.8E-2
Caudate nucleus	120	1.3E-13			426	8.2E-21	63	4.3E-5
Globus pallidus	54	4.9E-3	10	9.9E-2	294	4.6E-25	55	2.0E-10
Cingulate cortex	62	8.1E-4					36	2.2E-2
Parietal lobe	70	1.2E-2			320	2.4E-9	47	6.3E-3
Cerebellum	186	8.4E-2
Heart	86	1.8E-3
Cardiac myocytes	204	4.8E-25	34	1.1E-6	830	1.1E-66	123	5.4E-15
Smooth muscle	93	4.3E-3
Skeletal muscle	135	3.2E-2
Bronchial epithelial cells	67	2.8E-10	9	7.4E-2	262	3.8E-29	54	1.2E-13
Adrenal cortex	71	3.8E-7	14	3.3E-3	226	1.4E-5	36	9.9E-3
Thyroid	104	2.3E-17	15	5.3E-3	312	6.0E-16
Adipocyte	214	9.7E-10	33	1.8E-2	889	5.0E-18	124	3.8E-4
Uterus	65	1.3E-2					44	6.2E-3
Uterus corpus	85	4.3E-8	14	1.9E-2	361	7.1E-28	55	1.4E-6
Whole blood	106	6.2E-2
Bone marrow	53	2.7E-2
Lymph node	89	2.7E-9	15	8.3E-3	327	1.7E-16	55	1.9E-6
PB-CD14+ monocytes	224	2.1E-22	22	2.1E-3	953	1.2E-70	130	4.3E-10
CD8+ T-cells	210	2.2E-17	34	1.2E-4	856	5.5E-38	123	1.4E-8
PB-CD56+ NK cells	199	2.1E-13	29	2.4E-2	854	3.4E-44	116	1.5E-6
PB-CD19+ B-cells	205	3.3E-10			921	1.1E-47	128	2.7E-8
BM-CD34+	223	3.4E-9	34	3.4E-2	973	4.9E-30	140	1.3E-8
CD4+ T-cells	107	5.6E-9	17	1.8E-2	381	6.2E-11	59	4.3E-4
BM-CD71+ early erythroid	218	2.9E-8			911	9.9E-14	125	5.2E-3
BM-CD33+ myeloid	178	3.4E-3			770	1.1E-6	109	1.4E-2